Working at the interface of Medicine, Biology and Engineering, we strive to create a near-term, global impact by developing cutting-edge, bioinspired technologies in the longevity arena. Our innovations span from designing unique medical devices, biomaterials to valuable therapeutics and diagnostics, all aimed to be transformed into commercial products and solutions.
Reprogramming & Gene Therapy
We focus on developing precise and targeted methods for reprogramming aging cells by reducing global heterochromatin levels, modifying histone post-translational modifications, altering DNA methylation patterns, and other factors that influence gene activity, all of which are hallmark features of the aging process. Through these specific approaches, we aim to develop effective interventions to address age-related diseases and improve overall health in aging individuals.
Our research focuses on understanding the mechanisms by which autophagy impacts the hallmark features of aging, with the ultimate goal of developing targeted therapies to restore and improve cellular function. Specifically, we explore how autophagy can be utilized to reprogram aged cells, leading to improvements in cellular health and rejuvenation. We aim to develop effective interventions for age-related diseases and ultimately enhance healthspan by identifying and targeting key pathways involved in autophagy-mediated reprogramming.
Paving the way for fast and high throughput pre-clinical validations, we employ microfluidic technologies to build organs-on-chip models to evaluate the efficacy of our drug and treatment approaches.
Emergent mechanical control of vascular morphogenesis
Endothelium and Subendothelial Matrix Mechanics Modulate Cancer Cell Transendothelial Migration
A Microphysiological Model of Bone Development and Regeneration
Hippocampus of the APP NL-G-F mouse model of Alzheimer's disease exhibits region-specific tissue softening concomitant with elevated astrogliosis
Stromal cells regulate mechanics of tumour spheroid
Under review… coming soon!